What are PRP, CGF and PRF?
PRP (Platelet Rich Plasma) therapy is to undergo the centrifugation of the blood taken from the patient, to physically concentrate and inject the target tissue in order to obtain fast tissue rejuvenation and healing. PRP is in liquid form.
CGF (Concentrated Growth Factor) therapy is to perform tissue renewal by injecting concentrated growth factor plasma into the patient by physically or chemically activating the platelet plasma (doing activation while in the tube) by centrifuging the blood sample taken from the patient. While activation in PRP starts in tissue after injection, it takes place in the tube during CGF process.
PRF (Platelet Rich Fibrin) therapy is to obtain Fibrin-rich plasma by centrifuging the blood sample taken from the patient and running the clot mechanism. It is obtained as a clotted product in plasma gel consistency in PRF. Platelet rich part is taken and mixed with bone graft and applied to the target tissue.
Explanation
PRP, CGF and PRF treatment methods are actually built on exactly the same basis. The treatment origin is to create tissue regeneration by using the growth factors in the platelets in all three applications. The differences between these treatments are due to differences in the methods of obtaining plasma.
PRP History
It was first used in 1987 in open heart surgery.
PRP gained popularity after being applied to well-known NBA players in the 1990s.
How Rich should Platelet Rich Plasma be?
In Clinical Studies, the therapeutic threshold in PRP should be 1,000,000 plt / μl.
PRP Treatment Physiology
Wide variety of Growth Factors and 200 different proteins
Activation
VEGF
PDGF
FGF
EGF
TGF-β
Cell Growth Cell Formation Chemotaxis Cytokine Release Collagen Synthesis
Healing
How should the centrifuge device be?
Flying Rotor
No vibration
Should be set accordinf to RCF
Cooling and UV Sterile
How much and How to take PRP?
Buffy Coat = PLT + Leukocyte
If 1/4 dilution intake is made in 15 ml blood, a total of 1.5-2 ml PRP should be taken and applied to the target point.
The remaining PPP can be taken and applied around the target point separately.